Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence

Abstract Aberrant neural oscillations hallmark numerous brain disorders. Here, we first report a method to track the phase of in real-time via endpoint-corrected Hilbert transform (ecHT) that mitigates characteristic Gibbs distortion. We then used ecHT show aberrant oscillation hallmarks essential tremor (ET) syndrome, most common adult movement disorder, can be transiently suppressed transcranial electrical stimulation cerebellum phase-locked tremor. The suppression is sustained shortly after end and phenomenologically predicted. Finally, use feature-based statistical-learning neurophysiological-modelling ET mechanistically attributed disruption temporal coherence olivocerebellar loop, thus establishing its causal role. driven may future represent powerful neuromodulatory strategy treat